Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.
CITATION STYLE
Gabaldón, T. (2008). Large-scale assignment of orthology: back to phylogenetics? Genome Biology. https://doi.org/10.1186/gb-2008-9-10-235
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