Methods of synthesis of Pimavanserin: The first drug approved for the treatment of Parkinson’s disease psychosis (PDP)

Abstract

Pimavanserin (NuplazidTM) is the first FDA atypical antipsychotic drug approved for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis (PDP). Pimavanserin displays a unique pharmacological profile with nanomolar potency as a 5-HT2A receptor inverse agonist. Due to the importance of Pimavanserin for the field of neurological disorder, numerous reports have appeared in the literature dealing with the synthesis of Pimavanserin. In this article we collect, summarize and discuss the various synthetic strategies and judge their applicability for larger scale drug synthesis.