Formulation and evaluation of bilayer tablets of propanolol hydrochloride

Abstract

Propranolol hydrochloride bi-layer tablets were formulated consisting of two layers such as fast releasing layer and sustaining layer. Fast releasing layer was prepared using super-disintegrant such as sodium starch glycolate and sustaining release layer was prepared using hydrogels like Hydroxy propyl methyl cellulose (HPMCK4M) and Sodium Carboxy methyl cellulose (high viscosity grade) alone and in combination with an aim to attain zero order release after the initial burst of release. Selected formulations were subjected to Invitro drug release in simulated gastric fluid and simulated intestinal fluid which revealed that dissolution kinetics followed a first order release for formulations containing HPMC or NaCMC alone where as formulations containing combination of polymers followed a zero order kinetics. Analysis of variance showed a significant difference (p<0.05) in drug release among the formulations. Therefore hydrogels in appropriate proportions are suitable for formulating controlled release tablets to have a zero order release for watersoluble drugs like propranolol hydrochloride. © APTI All rights reserved.