Localization of P300 sources in schizophrenia patients using constrained BSS

Abstract

A robust constrained blind source separation (CBSS) algorithm has been proposed for separation and localization of the P300 sources in schizophrenia patients. The algorithm is an extension of the Infomax algorithm, based on minimization of mutual information, for which a reference P300 signal is used as a constraint. The reference signal forces the unmixing matrix to separate the sources of both auditory and visual P300 resulted from the corresponding stimulations. The constrained problem is then converted to an unconstrained problem by means of a set of nonlinear penalty functions. This leads to the modification of the overall cost function, based on the natural gradient algorithm (NGA). The P300 sources are then localized based on electrode - source correlations. © Springer-Verlag 2004.