ANTIBACTERIAL POTENTIAL OF BENZIMIDAZOLE CONTAINING HYBRID DERIVATIVES

Abstract

A wide range of bacterial infections are mitigated with antibiotics, however, repeated infections produced by importunate bacteria are obstructing effective treatment. Furthermore, the resistance of bacteria to the existing antibiotics is a significant and vexing problem of the day. The hybrid pharmacophore structural modification concept is now widely used to develop new medications with synergistic activity or increased medication efficacy. This review looks at the benzimidazole hybrids that have evolved in the last two decades and have probable antibacterial action. Structure-activity relationship and study of molecular interaction are also examined to locate the course for the intent and expansion of benzimidazole hybrids by means of good pharmacokinetic and pharmacodynamic profiles. Based on the findings, it can be inferred that such hybrids that have substitution on both ring benzimidazole, as well as other heterocyclic rings, have better antibacterial potential rather than the hybrids that have substitution only on a single ring. Findings also indicate the crucial positions for substitution to have maximum antibacterial potential. The antibacterial activity not only depends on the substitution of rings but also depends on the attachment of the linker group between two rings. Resulting, it is thought worthwhile to synthesize novel benzimidazole hybrids having appropriate linkers and substituents with the goal of having potent bactericidal activity.