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Highly diastereoselective aldol reaction with α-CF 3-substituted enolates

Angewandte Chemie - International Edition (2006) 45(31) 5174-5176
DOI: 10.1002/anie.200600927
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Abstract

(Chemical Equation Presented) A CF3 group and a chiral auxiliary are the key features of the Ti enolate used in the aldol reaction shown above. The syn aldol is formed in good yields, and defluorination leading to the vinylic CF2 product is not observed. The aldol product may be used to prepare more elaborate CF3-containing compounds, for instance, through the corresponding 1,3-diol. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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Franck, X., Seon-Meniel, B., & Figadère, B. (2006). Highly diastereoselective aldol reaction with α-CF 3-substituted enolates. Angewandte Chemie - International Edition, 45(31), 5174–5176. https://doi.org/10.1002/anie.200600927

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