Abstract
Background: LTC4S is required for Orai1/Orai3 LRC channel activation. However, the role of LTC4S in neointimal hyperplasia is unknown. Results: LTC4S knockdown inhibited neointimal hyperplasia. Akt phosphorylation was decreased in injured arteries, and knockdown of Orai3 or LTC4S restored Akt phosphorylation. Conclusion: LTC4S is required for neointimal hyperplasia. Significance: LTC4S is a potential therapeutic target for vascular occlusive diseases.
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CITATION STYLE
Zhang, W., Zhang, X., González-Cobos, J. C., Stolwijk, J. A., Matrougui, K., & Trebak, M. (2015). Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia. Journal of Biological Chemistry, 290(8), 5015–5027. https://doi.org/10.1074/jbc.M114.625822
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