Abstract
Leupeptins which have anti-Plasmin activity and inhibit trypsin, papain and blood coagulation have been obtained from cultured broths of various species of Actinomycetes. Two leuPePtins which were leupeptins Pr (C21H40O4N6) and Ac (C20H38O4N6) were isolated and characterized. They gave their di-n-butyl acetals, dihydroleupeptins and leupeptin acids Physical and chemical properties of these leupeptins and their derivatives were described. © 1969, The Pharmaceutical Society of Japan. All rights reserved.
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CITATION STYLE
Kondo, S. I., Kawamura, K., Iwanaga, J., Hamada, M., Aoyagi, T., Maeda, K., … Umezawa, H. (1969). Isolation and Characterization of Leupeptins produced by Actinomycet. Chemical and Pharmaceutical Bulletin, 17(9), 1896–1901. https://doi.org/10.1248/cpb.17.1896
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