Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells

Abstract

Background: The transcriptional regulation of human dendritic cells (DCs) differentiation and maturation remains incompletely understood. Results: VentX knockdown impaired DCs differentiation and maturation whereas VentX overexpression counteracted the inhibitory effects of corticosteroid on DC activation. Conclusion: VentX is critical for DCs differentiation and maturation. Significance: VentX may be a novel target to modulate DCs functions and manage inflammatory diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.