Preemptiveanalgesiceffectofketamineinchildrenwithlowerabdominalsurgery

Abstract

Objective: Preemptive an algesic effect to flow dose ketamine has been supported by clinical studies in adults. The aim of this study was to evaluatethe analgesic effect of ketamine applied at different times in children who under went lower abdominal surgery. Materialand Methods:A total of 90 children having ASAI-II physical status between 3and12 was randomly divided into three group saspre, intand post groups. Ketamine were given to these groups in the following manner respectively; 1mg/kg intravenous ketamine before incision (pre-incisional); the same dose ketamine 10minutes following the first incision (intraoperative); and ketamine at the end of the surgical operation (postoperative). The pain of patients was assessed by post operative pain scale(CHIPPS) in child renand infants; these dation status of children was assessed by Ramsey'ssedation scale.The first analgesic requirement time was recorded. Results: No significant difference was found in demo graphic characteristics of the three groups(p>0.05).Lower CHIPPS scores were found in Group Post through out all measurement periods (p<0.05). Group Post was found to have significantly highersedation levels compared with the other two groups (p=0.003). Conclusion: No analgesic effect was obtained using by pre-incisiona land intra operative i.v.1mg/kg ketamine, during lower abdominal surgery in children. Further studies with different drug sareneeded to clarify this topic. © Trakya University Faculty of Medicine.