LEUKOTRIENE B4: A MEDIATOR OF VASCULAR PERMEABILITY

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Abstract

Intradermal injection of leukotriene B4 (LTB4) or prostaglandin E2 (PGE2), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea‐pig and rat. Intradermal injection of LTB4 together with PGE2 produced a significant increase in plasma exudation in the rabbit, guinea‐pig and rat. Intradermal injection of LTB4 or PGE2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea‐pig. LTB4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE2 which was a potent vasodilator in this species. It is concluded that LTB4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE2. 1981 British Pharmacological Society

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BRAY, M. A., CUNNINGHAM, F. M., FORD‐HUTCHINSON, A. W., & SMITH, M. J. H. (1981). LEUKOTRIENE B4: A MEDIATOR OF VASCULAR PERMEABILITY. British Journal of Pharmacology, 72(3), 483–486. https://doi.org/10.1111/j.1476-5381.1981.tb11000.x

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