A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects

Abstract

This study in normotensive subjects compared the duration and consistency of action of amlodipine (5 mg) and nifedipine GITS (60 mg) by assessment of the attenuation of pressor responses to noradrenaline and angiotensin II. Both drugs significantly attenuated pressor responses to both vasoconstrictors at 6 and 24 h post‐dose with rightward shifts of up to 2.3‐fold in the dose‐response curves. There was significantly less pharmacokinetic variability with amlodipine: for example, intra‐subject variability was 33% with amlodipine and 59% with nifedipine GITS. There were no significant differences in the pressor dose ratios up to 48 h post‐dose with amlodipine whereas there was a significant and progressive reduction in the pressor dose ratios with nifedipine. These results suggest that both drugs are broadly comparable as once daily treatments but amlodipine displayed less intra‐ and inter‐subject variability and provided a significantly more sustained effect with a reserve of pharmacological activity up to 48 h post‐dose. 1993 The British Pharmacological Society