Safety evaluation of hot-water extract of Hatakeshimeji (Lyophyllum decastes Sing.)

Abstract

An extract of Hatakeshimeji (Lyophyllum decastes Sing.) was orally administrated once to male and female mice and to male mice for 20 weeks. We macroscopically observed general symptoms, the presence or absence of death during a dose period, and the presence or absence of abnormality upon completion. Results suggest that the general observation of symptoms and increase of weight were unchanged and no death or abnormal findings were present at autopsy. In addition, the extract of Hatakeshimeji (2.88 g) was administrated orally to 11 adults for two weeks during which we assessed its safety by conducting blood tests, urine tests, and blood pressure and body measurement checks. Consequently, there were no clinical problems observed with regard to blood test results, hepatic and renal functions, glucose and lipid metabolisms, and blood pressure. Likewise, analysis of agaritine from hot-water extracts of Hatakeshimeji showed no such problems. These results suggest that the extract of Hatakeshimeji is a safe food and may perform some health functions.