Climbing Neuronal Activity as an Event-Based Cortical Representation of Time

Abstract

The brain has the ability to represent the passage of time between two behaviorally relevant events. Recordings from different areas in the cortex of monkeys suggest the existence of neurons representing time by increasing (climbing) activity, which is triggered by a first event and peaks at the expected time of a second event, e.g., a visual stimulus or a reward. When the typical interval between the two events is changed, the slope of the climbing activity adapts to the new timing. We present a model in which the climbing activity results from slow firing rate adaptation in inhibitory neurons. Hebbian synaptic modifications allow for learning the new time interval by changing the degree of firing rate adaptation. This event-based representation of time is consistent with Weber's law in interval timing, according to which the error in estimating a time interval is proportional to the interval length.