Heat Inactivation of Influenza Viruses—Analysis of Published Data and Estimations for Required Decimal Reduction Times for Different Temperatures and Media

Abstract

(1) Background: Influenza is a viral infection that has claimed many millions of lives over the past 100 years, and there is always a risk that a new influenza virus will emerge and cause another pandemic. One way to reduce such a potential new influenza virus will be heat inactivation. The question in this study is how much the heat sensitivities of previous influenza viruses differ. If they are very similar, it is expected that a new influenza virus can be inactivated with the same heat parameters as previous influenza viruses. (2) Methods: Through a literature search, published heat inactivation results are compiled and analyzed using Arrhenius models and regression equations for decimal reduction times for different temperatures and media determined. (3) Results: There are about 50 studies on heat inactivation of human and avian influenza viruses so far, showing large differences in heat sensitivity of influenza viruses in different media. However, within a single medium the differences between viruses are rather small. (4) Conclusions: At a temperature of 60 °C, previous influenza viruses can be reduced by 4 or more orders of magnitude within approximately 30 min in almost all media, and this is likely to be true for a potential new influenza virus. Further studies, especially on human influenza viruses, would be desirable.