Structure-based design of a new class of highly selective pyrazolo[3,4-d]pyrimidines based inhibitors of cyclin dependent kinases

Abstract

Structure-based design approach was successfully used to guide the evolution of a pyrazolo[3,4-d]pyrimidine scaffold yielding a new structural class of highly selective inhibitors of cyclin dependent kinases capable to interact with an identified part of the protein. Several compounds from this series displayed potent and selective activity against CDK2. © ARKAT USA, Inc.