High antioxidant level in cajanus sajan reduces blood glucose level and improves blood lipid profile of rats as diabetes mellitus models

Abstract

Hyperglycemia in DM was able to increase glucose auto-oxidation, protein glycation, and polyol pathway activation. As a result, it can accelerate the formation of reactive oxygen compounds acting as the main factor causing DM complication. Before we evaluated pigeon bean Tempe with formulations of 25%, 50%, and 75%, we tested the number and activity of its antioxidant. Then we substituted it on standard feed for 14 days to find the effects on glucose level and lipid profile. The effects were then compared to that before the intervention. The result showed that the total and activity of antioxidants in pigeon bean Tempe (Cajanus sajan) was 15% and 41.30% respectively. On the other side, pigeon bean Tempe with a formulation of 75% was more able to reduce blood glucose level, total cholesterol, triglycerides, and LDL-cholesterol by 44.08%, 34.38%,35.80%, and 43.22% respectively (p<0.05) if compared to pigeon bean Tempe with formulations of 25% and 50%. Meanwhile, pigeon bean Tempe with the formulation of 75% provided better effects for an increase of HDL level 56.20% (p<0.05). All test results on Tempe formulation used were compared to that before the intervention.