Evaluation of the Acute Toxicity of a Mosquito Coil Based-Meperfluthrin

Abstract

Coils or burning coils are human biting insect repellents (flies, bees, wasps, mosquitos…). These products are widely used to fight against malaria and dengue vectors in tropical countries. The aim of this study was to assess the acute toxicity by oral, dermal, ocular and pulmonary routes of a mosquito coil and its classification in the globally harmonized system of classification and labeling of chemicals (GHS). Various tests were carried out according to OECD 423 guidelines (2001) for the acute toxicity by oral route, OECD 436 (2009) for the acute toxicity test by inhalation and OECD 402 (1987) and 404 (2015. Signs of toxicity such as apathy and drowsiness were observed at the dose of 2000mg/Kg by oral route. Toxicity through inhalation is characterized by a lung disease associated with bronchial and interstitial pneumonia, a tubulointerstitial nephritis with renal impairment and a LC50 (rat) ranging from 5 to 10mg/l/4 h. The coil studied was non-irritating by ocular and dermal routes. Results showed a high toxicity of the coil by pulmonary route. The LC50 (rat) between 5 and 10mg/l/ suggests a classification in category 3 of the product studied in the Globally Harmonized System of classification and labeling of chemicals (GHS).