Tuberculosis remains the world's second leading infectious cause of death, with nearly one-third of the global population latently infected. Treatment of latent tuberculosis infection is a mainstay of tuberculosis-control efforts in low-to medium-incidence countries. Isoniazid monotherapy has been the standard of care for decades, but its utility is impaired by poor completion rates. However, new, shorter-course regimens using rifamycins improve comple- tion rates and are cost-saving compared with standard isoniazid monotherapy. We review the currently available therapies for latent tuberculosis infection and their toxicities and include a brief economic comparison of the different regimens. © 2012 Norton and Holland, publisher and licensee Dove Medical Press Ltd.
CITATION STYLE
Norton, B. L., & Holland, D. P. (2012). Current management options for latent tuberculosis: A review. Infection and Drug Resistance. Dove Medical Press Ltd. https://doi.org/10.2147/idr.s29180
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