In this paper we report the development of two attachments to a commercial cell phone that transform the phone's integrated lens and image sensor into a 350× microscope and visible-light spectrometer. The microscope is capable of transmission and polarized microscopy modes and is shown to have 1.5 micron resolution and a usable field-of-view of ~150×150μm with no image processing, and approximately 350×350 μm when post-processing is applied. The spectrometer has a 300 nm bandwidth with a limiting spectral resolution of close to 5 nm. We show applications of the devices to medically relevant problems. In the case of the microscope, we image both stained and unstained blood-smears showing the ability to acquire images of similar quality to commercial microscope platforms, thus allowing diagnosis of clinical pathologies. With the spectrometer we demonstrate acquisition of a white-light transmission spectrum through diffuse tissue as well as the acquisition of a fluorescence spectrum. We also envision the devices to have immediate relevance in the educational field. © 2011 Smith et al.
CITATION STYLE
Smith, Z. J., Chu, K., Espenson, A. R., Rahimzadeh, M., Gryshuk, A., Molinaro, M., … Wachsmann-Hogiu, S. (2011). Cell-phone-based platform for biomedical device development and education applications. PLoS ONE, 6(3). https://doi.org/10.1371/journal.pone.0017150
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