The study of adsorption and desorption of antibiotics on the surface of nanoparticles

Abstract

Nanotechnology is a field that is gaining more and more importance in the modern world. It is noted that the use of nanoparticles (balls with a diameter of from several to several hundred nm) as carriers of drugs gives an opportunity for their controlled and sustained release (1, 2). Nanoparticles as a potential drug carrier for sustained release may enhance the effectiveness of antibiotics. In order to examine the effects of antibiotics with nanoparticles, an attempt was made to deposit on them three drugs differing in chemical structure. These were chloramphenicol, gentamicin and ceftazidime. The aim of this study was to determine the degree of adsorption of the drug on the surface of nanoparticles and to examine the process of desorption from the surface of silica nanoparticles. The results of the study indicate that in the case of chloramphenicol it is essentially a process of chemisorption, and for gentamicin and ceftazidime both physical and chemical adsorption, without there being any clearly defined relationship between this two processes. The purpose of the nanoparticles as drug carriers is to obtain controlled and prolonged exposure to the drug. Ceftazidime, as the compound with the largest number of double bonds and a large number of groups that can form hydrogen bonds (carbonyl, amino groups), was the most adsorbed.