Clonal monocytosis of clinical significance

Abstract

The World Health Organization (WHO) diagnostic criteria for chronic myelomonocytic leukemia (CMML) include clinical and morphological features; however, demonstrating clonality is not an absolute requirement for making the diagnosis.1 In this issue of Blood, Cargo et al show that patients with clonal monocytosis identified by targeted gene sequencing have a clinical outcome similar to that of overt WHO-defined CMML.2