Synthesis and characterization of functionalized modified PVC-chitosan as antimicrobial polymeric biomaterial

Abstract

Amino acetic acid modified poly(vinyl chloride), MPVC, was obtained by chemical modification of PVC using glycine methyl ester. MPVC was used as a precursor to prepare some functionalized MPVC conjugates to be used in biomedical applications. MPVC-Cs was prepared by the chemical reaction of MPVC with chitosan as a natural polymer in absence and presence of epichlorohydrin (Ech) as a crosslinking agent. Further chemical modification was performed by the reaction of MPVC with Cs and salicylic acid in the absence in presence of Ech via one-pot reaction. The chemical structure of the formed MPVC, MPVC-Cs, MPVC-Cs/POH, MPVC-Cs/SA and MPVC-Cs/POH/SA was confirmed by the FTIR spectroscopic analysis, scanning electron microscopy, and thermogravimetric analysis (TGA). The antibacterial activity of the prepared MPVC and its conjugates was investigated against two Gram +ve bacteria (Staphylococcus aurous and Listeria monocytogenes) and (Escherichia coli and Salmonella typhi) as Gram −ve bacteria in addition to the Catondida albicans as yeast. Minimum inhibition concentration (MIC) was also determined for the prepared materials.