A fluorescent activatable probe for imaging intracellular Mg2+

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Abstract

An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg2+ without interference from Ca2+ is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg2+ due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core.

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Treadwell, R., De Moliner, F., Subiros-Funosas, R., Hurd, T., Knox, K., & Vendrell, M. (2018). A fluorescent activatable probe for imaging intracellular Mg2+. Organic and Biomolecular Chemistry, 16(2), 239–244. https://doi.org/10.1039/c7ob02965a

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