Strategies to increase the effectiveness of wound healing therapy with mesenchymal stem cells in diabetic patients

Abstract

Administration of mesenchymal stem cells (MSC) into the wound seems a promising therapy in the management of hard-to-heal wounds in diabetic patients. We still do not have algorithms that would precisely define appropriate use of this therapy. However, the latest research results indicate multidirectional effects of MSC therapy (improvement of blood supply and tissue granulation within the wound, formation of superficial skin layers), as well as differences in the treatment efficacy between transplantation of cells obtained from a healthy person (allogeneic graft) and transplantation of cells obtained from the diabetic host (autologous graft). Various modifications of MSC therapy lead to more rapid wound healing, and this therapy may be a breakthrough in the treatment of chronic wounds in diabetic patients. in this article, we reviewed the up-to-date knowledge on the use of MSC in the treatment of hard-to-heal wounds in diabetes.