Pharmacogenomic approaches to study the effects of antihypertensive drugs

Abstract

Pharmacogenomic studies aim to clarify the role of various genes and their variations in relation to the effects of antihypertensive drugs to establish a personalized pharmacotherapeutic treatment based on a patients genetic background. Until recently, there have been numerous pharmacogenetic/ pharmacogenomic studies on antihypertensive drugs using candidate genes, but only a few genome-wide approaches have been completed. In this review article, we discuss current trends and future directions of pharmacogenomic studies on antihypertensive drugs. © 2012 The Japanese Society of Hypertension. All rights reserved.