Antitumor and apoptotic effects of bergaptol are mediated via mitochondrial death pathway and cell cycle arrest in human breast carcinoma cells

14Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

The aim of the present research work was to investigate the anti-cancer and apoptotic effects of bergaptol in human breast cancer cells (MCF-7). The effects on cell cycle arrest and caspase activation were evaluated. MTT assay was used to evaluate the effect of the compound on cell viability. Cellular morphology was demonstrated by fluorescence microscopy. Flow cytometry was used to analyze effect of bergaptol on cell cycle and apoptosis. The results revealed that bergaptol induced dose-dependent cytotoxic effect on MCF-7 cell viability showing IC50 value of 52.2 µM. Bergaptol induced both early and late apoptosis in concentration-dependent manner. After treatment with bergaptol, an increase in the proportion of cells in the S-phase (37.2, 45.3 and 65.1% as compared to 28.6% in untreated cells) and a reduction in the fraction of cells in the G1 phase (44.1, 41.6 and 35.2% as compared to 51.2% in the untreated cells) was observed. urgent need for chemotherapeutic agents with low toxicity and high selectivity for targeting malignant.

References Powered by Scopus

Global cancer statistics

31577Citations
N/AReaders
Get full text

Apoptosis: A Review of Programmed Cell Death

10677Citations
N/AReaders
Get full text

Natural products as sources of new drugs over the last 25 years

3836Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Chemistry and health effects of furanocoumarins in grapefruit

142Citations
N/AReaders
Get full text

Anticancer potential of furanocoumarins: Mechanistic and therapeutic aspects

133Citations
N/AReaders
Get full text

Anticancer Potential of Coumarin and its Derivatives

111Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ge, Z. C., Qu, X., Yu, H. F., Zhang, H. M., Wang, Z. H., & Zhang, Z. T. (2016). Antitumor and apoptotic effects of bergaptol are mediated via mitochondrial death pathway and cell cycle arrest in human breast carcinoma cells. Bangladesh Journal of Pharmacology, 11(2), 489–494. https://doi.org/10.3329/bjp.v11i2.24644

Readers' Seniority

Tooltip

Professor / Associate Prof. 3

43%

PhD / Post grad / Masters / Doc 3

43%

Researcher 1

14%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 3

38%

Chemistry 3

38%

Agricultural and Biological Sciences 1

13%

Biochemistry, Genetics and Molecular Bi... 1

13%

Save time finding and organizing research with Mendeley

Sign up for free