The Prognostic Value of the C-reactive Protein/Prognostic Nutritional Index Ratio in Stage III and IV Laryngeal Cancer Patients Treated with Radiotherapy

Abstract

Objective Patients with advanced laryngeal cancer have a poor prognosis. The purpose of this work was to analyze the connection between clinical factors and survival and to try to identify survival prognostic factors. Methods Sixty-one laryngeal cancer patients received radiotherapy. All of their clinicopathologic material was gathered from a retrospective review of the medical records and subjected to further analysis. We examined the prognostic significance of the C-reactive protein (CRP)/prognostic nutritional index (PNI) ratio. Results We assessed the CRP and PNI levels before radiotherapy. An analysis of overall survival (OS) of patients with high CRP/PNI was markedly shorter than for those patients with a low CRP/PNI (P=0.010). Multivariable analysis showed that a high CRP/PNI ratio was a disadvantageous independent prognostic marker. Conclusions The data show that CRP/PNI may be used as a prognostic indicator for laryngeal cancer patients treated with radiotherapy.