Optimization of electrospinning parameters and degradation properties for Gelatin/CMC nanofibers

Abstract

This research aimed to enhance strength of Nanofiber like Biopolymer as raw material for characterization which is popularly used in food and cosmetic industry and as medical material because it did not hazardously affect human body. This study employed Nano fiber characterization with Electrospinning Method by using gelatin/CMC, common and inexpensive biopolymer with cellulose that could strengthen Nanofiber.The fabrication of fiber scaffold by electrospinning method produced nano-fiber by dissolving gelatin in organic solvent, 2,2,2-trifluoroethanol, and dissolving CMC in DI water. The design of experiment was surface responds and 3 factors were analyzed including 1) gelatin concentration varied from 8-12%, CMC concentration in range of 0.6-1.0% and 3) mixture percent of CMC in range of 10-30%. After the test of tension, the highest value was 13.99Mpaderived from gelatin with 10.64% concentration, CMC with 0.81%concentration and mixture of CMC with 17.79% concentration. After that, the work piece obtained from mixing CMC with concentration at 10, 20 and 30%, 10% Gelatin and 0.80%CMC as constant due to highest volume of product from such 3 values, was tested for decomposition compared with pure-scaffold gelatin. The findings revealed that decomposition rate of CMC mixture at 20% concentration was slowest and it could be found that the result of tension testing and decomposition testing was consistent. That is, 10% Gelatin, 0.8% CMC and 20% CMC mixture gave the best value in both experiments. Additionally, it was obvious that pure-scaffold gelatin took only 1 hour to totally decompose while CMC mixture at 10%, G91 that degraded entirely in 24 hours, CMC mixture at 30%,G73 degraded in 48 hours, CMC mixture at 20%,G82 degraded in 54 hours to decompose entirely with CMC mixture. It means that using CMC which is cellulose derivative as ingredient in scaffold gelatin could strengthen it better.