OBJECTIVE: To study the profile of associated autoimmune diseases in a series of patients with systemic lupus erythematosus (SLE) and see if such associations are linked to IgA deficiency. METHODS: Two hundred eighty-one patients with SLE were studied for Ig A levels by nephelometry. Levels equal to or under 0.05g/dL were considered as IgA deficiency. Epidemiological and clinical data, including the presence of associated autoimmune diseases, were extracted from the patient's charts. RESULTS: Ig A deficiency was found in 6% of the patients. In 30.2% of SLE patients, there was at least one more autoimmune disease; Hashimoto thyroiditis and Sjögren's syndrome were the most common. No association between the occurrence of associated autoimmune disease with IgA deficiency was found. CONCLUSIONS: There is a high prevalence of autoimmune diseases associated with SLE. IgA deficiency does not affect the presence of these associations.
CITATION STYLE
Linzmeyer, G. F. A., Miyake, F. K., Dos Santos, T. A. F. C. G., & Skare, T. L. (2020). Serum immunoglobulin a deficiency and autoimmune comorbidities: A crossectional study in 281 patients with systemic lupus erythematosus. Revista Da Associacao Medica Brasileira, 66(6), 752–756. https://doi.org/10.1590/1806-9282.66.6.752
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