Enantioselective synthesis of 2-substituted cyclobutanones

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Abstract

(equation presented) An enantioselective synthesis of 2-substituted cyclobutanones has been achieved by sequential application of the titanium-mediated cyclopropanation of α-hydroxy esters and the pinacol-type rearrangement of the resulting α-hydroxycyclopropylcarbinols.

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Cho, S. Y., & Cha, J. K. (2000). Enantioselective synthesis of 2-substituted cyclobutanones. Organic Letters, 2(9), 1337–1339. https://doi.org/10.1021/ol005820v

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