Towards a gene expression biomarker set for human biological age

Abstract

We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≤75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger biological age. Those with 'younger' gene expression patterns demonstrated higher muscle strength and serum albumin, and lower interleukin-6 and blood urea concentrations relative to 'biologically older' individuals (odds ratios 2.09, 1.64, 0.74, 0.74; P = 2.4 3 10-2, 3.5 3 10-4, 1.8 3 10-2, 1.5 3 10-2, respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age. © 2013 The Authors. © 2013 The Authors. © 2013 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.