Clinical controlled study of shenmai injection and aminophylline on diaphragm fatigue

Abstract

OBJECTIVE: To compare the therapeutic effect of Shenmai injection (SM) and aminophylline (AP) on diaphragm fatigue in chronic obstructive pulmonary disease (COPD). METHODS: Sixty-four COPD patients with respiratory failure and diaphragm fatigue were randomly divided into 2 groups: (1) SM group (33 patients), treated with oxygen inhalation and anti-infection agents, and SM injection (SM 40 ml + 10% glucose 100 ml), (2) AP injection group (31 patients), treated with AP 0.25 g plus 10% glucose 100 ml, and the same comprehensive treatment. To investigate the initial time of diaphragm fatigue disappearance, the maintaining effect of 24 hours of drug administration, and the arterial blood gas analysis. RESULTS: The effect in 30 min and maintaining effect in 24 hours in SM group were better than those in the AP group. In both groups, PaO2 increased and PaCO2 decreased. CONCLUSION: The therapeutic effect of SM on COPD patients with respiratory failure and diaphragm fatigue was better than those of AP.