Integrin scintimammography using a dedicated breast imaging, solid-state γ-camera and 99mTc-labelled NC100692

Abstract

Objective: Integrin scintimammography with NC100692 and a dedicated γ-camera, LumaGEM, based on semi-conductor technology, was performed to investigate the detection ability of this combination in breast cancer. Methods: Eight patients with a high suspicion of breast cancer were administered 600-750MBq 99m Tc-labelled NC100629. Two acquisitions using a cranio-caudal and a lateral view were used, with moderate compression of the breast. Results: LumaGEM scintigraphy revealed 9 of 11 malignancies, sized 6-20mm. Two lesions in patients with multicentric disease were not diagnosed, one of which measured only 2.5mm. In one patient, the procedure was inconclusive, due to major breast hypertrophy. Conclusion: The combined use of NC100629 and a dedicated γ-camera for breast imaging was highly effective in diagnosing breast cancer. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd.