Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems. A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species restriction of infection with hepatitis A virus as well as linking cytosolic immune sensing in infected hepatocytes with innate effector functions and protective adaptive immunity.
CITATION STYLE
Knolle, P. A. (2017). Hitting the right button: MAVS-mediated defense against HAV infection. Cell Research, 27(1), 7–8. https://doi.org/10.1038/cr.2016.139
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