Polyellisin, a novel polyketide from cultures of the basidiomycete Polyporus ellisii

Abstract

Polyellisin (1), an unprecedented polyketide possessing a tricyclic system sharing a spiroketal carbon, was isolated from cultures of the basidiomycete Polyporus ellisii. The structure with absolute configuration was elucidated by means of spectroscopic methods and the single crystal X-ray diffraction. Polyellisin showed NO production inhibition with an IC50 value of 17.2 μM.