GOLPH3, a good prognostic indicator in early-stage NSCLC related to tumor angiogenesis

15Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

Background: Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Materials and Methods: Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of intratumoral microvessel density (MVD) by counting CD-34 positive immunostained endothelial cells. Correlations of expression with MVD, clinicopathologic features and clinical prognosis were analyzed. Results: A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. However, we do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), although higher MVD was positively associated with GOLPH3 overexpression (p>0.001). Expression of GOLPH3 was found to be an independent prognostic factor in earlystage NSCLC patients, those expressing high levels of GOLPH3 exhibiting a substantially lower 5-year overall survival than GOLPH3-negative patients (adjusted HR =1.899, 95% CI: 1.021-3.532, p=0.043). Conclusions: High expression of the GOLPH3 protein is common in early-stage NSCC, and is closely associated with tumor progression, increased tumor angiogenesis, and poor survival. We conclude a possibility of its use as a diagnostic and prognostic marker in early-stage NSCC patients.

Cite

CITATION STYLE

APA

Lu, M., Tian, Y., Yue, W. M., Li, L., Li, S. H., Qi, L., … Tian, H. (2014). GOLPH3, a good prognostic indicator in early-stage NSCLC related to tumor angiogenesis. Asian Pacific Journal of Cancer Prevention, 15(14), 5793–5798. https://doi.org/10.7314/APJCP.2014.15.14.5793

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free