Assessment of airway remodeling in asthma: Volumetric versus surface quantification approaches

Abstract

This paper develops a volumetric quantification approach of the airway wall in multi-detector computed tomography (MDCT), exploiting a 3D segmentation methodology based on patient-specific deformable mesh model. A comparative study carried out with respect to a reference 2D/3D surface quantification technique underlines the clinical interest of the proposed approach in assessing airway remodeling in asthmatics and in evaluating the efficiency of therapeutic protocols. © Springer-Verlag Berlin Heidelberg 2006.