Abstract
A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g−1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples.
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CITATION STYLE
Roy, B., Vo Duy, S., Puy, J.-Y., Martin, C., Guitton, J., Dumontet, C., … Lefebvre-Tournier, I. (2012). Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples. Journal of Functional Biomaterials, 3(1), 131–142. https://doi.org/10.3390/jfb3010131
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