Primary diffuse large B cell lymphoma of the spleen

Abstract

Diffuse large B cell lymphoma of the spleen is a form of splenic lymphoma, a rare primary neoplasm of the spleen. The clinical presentation is nausea, fatigue, weight loss, and other nonspecific symptoms. The most often seen laboratory finding is anemia. The first sonographic findings are typically splenomegaly and a well-defined hypoechoic mass. Most cases are treated with splenectomies. If the malignancy is confined to the spleen, the prognosis is favorable, but metastasis beyond the spleen is associated with a poor outcome. This case presents a classic case of diffuse large B cell splenic lymphoma with extension into the hilar lymph nodes. © 2010 The Author(s).