The first total synthesis of aspergillusol A, an α-glucosidase inhibitor

Abstract

The first total synthesis of aspergillusol A, an α-glucosidase inhibitor, was accomplished in an overall high yielding reaction sequence. A convergent synthetic approach was adopted; the erythritol segment of the molecule was derived from L-arabinose, whereas hydroxyphenylpyruvic acid oxime was built up from 4-hydroxybenzaldehyde.