Thai fruits exhibit antioxidant activity and induction of antioxidant enzymes in HEK-293 cells

Abstract

The cellular antioxidant enzymes play the important role of protecting the cells and organisms from the oxidative damage. Natural antioxidants contained in fruits have attracted considerable interest because of their presumed safety and potential nutritional value. Even though antioxidant activities ofmany fruits have been reported, the effects of phytochemicals contained in fruits on the induction of antioxidant enzymes in the cells have not been fully defined. In this study, we showed that extracts from Antidesma ghaesembilla, Averrhoa bilimbi, Malpighia glabra,Mangifera indica, Sandoricumkoetjape, Syzygiummalaccense, and Ziziphus jujuba inhibited H2O2-induced intracellular reactive oxygen species production in HEK-293 cells. Additionally, these Thai fruit extracts increased themRNAand protein expressions of antioxidant enzymes, catalase, glutathione peroxidase-1, andmanganese superoxide dismutase. The consumption ofThai fruits rich in phenolic compounds may reduce the risk of oxidative stress.