A Facile Synthesis of 6-Chloro- d -tryptophan

  • Moriya T
  • Hagio K
  • Yoneda N
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Abstract

A nonnutritive sweetener, 6-chloro-d-tryptophan (4), was synthesized from d-tryptophan (1) by nitration, hydrogenation and diazotization, followed by a reaction with cuprous chloride. The optical rotation of 4 agreed with that of an authentic sample which had been prepared by the resolution of racemic 4 methanesulfonate.

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Moriya, T., Hagio, K., & Yoneda, N. (1975). A Facile Synthesis of 6-Chloro- d -tryptophan. Bulletin of the Chemical Society of Japan, 48(7), 2217–2218. https://doi.org/10.1246/bcsj.48.2217

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