Premature menarche without other evidence of precocious puberty

Abstract

The authors describe 4 young girls with recurrent vaginal bleeding in the absence of other signs of precocious sexual development. Investigation showed low estrogen levels in 2 of them, and basal gonadotrophins were in the upper part of the prepubertal range. The authors believe that the isolated early menstruation in these patients was possibly related to increased sensitivity of the endometrium to estrogens.