Ischaemic complications of Glypressin in liver disease: A case series

Abstract

Aim: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin). Methods: We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so. Results: Two patients were obese and developed extensive abdominal wall skin necrosis. The third patient had lower limb chronic venous insufficency and developed extensive necrosis of both lower limbs. Conclusions: With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise. Earlier recognition and treatment may lead to improved outcome. © 2007 The Authors.