A mini review on production of pluripotency factors (Oct4, Sox2, Klf4 and c-Myc) through recombinant protein technology

Abstract

The four transcription factors Oct4, Sox2, Klf4 and c-Myc are highly expressed in embryonic stem cells (ESC) and their overexpression can induce pluripotency, an ability to differentiate into all cell types of an organism. The ectopic expression such transcription factors could reprogram somatic stem cells to be induced pluripotency stem cells (iPSC), an embryonic stem cells-like. The production of recombinant pluripotency factors gain interests due to the high demand from the generation of induced pluripotent stem cells in regenerative medical therapy recently. The focus of review is to demonstrate the recent advances in recombinant pluripotency factor production using various hosts.