A nomogram to predict overall survival of patients with early stage non-small cell lung cancer

Abstract

Background: Nomograms have been widely used for estimating cancer prognosis. The aim of this study was to construct a clinical nomogram that would well predict overall survival of early stage non-small cell lung cancer (NSCLC) patients after surgery resection. Methods: A total of 443 patients diagnosed with pathologic stage I and II NSCLC who had undergone curative resection without neoadjuvant chemotherapy or radiotherapy were recruited and analyzed. The log-rank test and multivariate Cox regression analysis were used to select the most significant predictors in the final nomogram for predicting overall survival. Furthermore, the model was validated by bootstrap methods and measured by concordance index (C-index) and calibration plots. Results: Four independent predictors for overall survival were identified and included into the delineation of the nomogram (tumor differentiation, station of sampled lymph nodes, pathologic T and pathologic N). The model showed comparatively stable discrimination (bootstrap-corrected C-index =0.622, 95% CI: 0.572-0.672) and good calibration. Conclusions: We successfully developed a nomogram incorporating available clinicopathological variables to predict overall survival of early stage NSCLC patients after surgery resection, which might help clinician select better appropriate treatment decisions.