S57. SLEEP QUALITY AND THE METABOLIC SYNDROME IN CHRONIC SCHIZOPHRENIC INPATIENTS

Abstract

Background: Poor sleep quality has been frequently noted in normal populations with metabolic syndrome (MetS). There were little evidences on the relations between sleep problem and metabolic syndrome in schizophrenia. The authors examined the association of sleep quality and metabolic syndrome in schizophrenic patients using actigraphy. Method(s): A total of 101 schizophrenic patients were included in this study. Fifty-four (53.4%) patients met the criteria of MetS. Self-assessment of subjective sleep quality, daytime sleepiness, physical activities were measured using Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and International Physical Activity Questionnaire (IPAQ), respectively. Psychopathology was assessed by Positive and Negative Syndrome Scale (PANSS). Objective sleep quality and physical activity were measured by Actigraph (ActiGraph wGT3X-BT). Actigraph was applied to each patient's dominant wrist for 1 week. Result(s): There were no significant differences on gender, age, marital status, educational level, duration of illness between patients with MetS and non- MetS. Scores of PSQI, ESS, IPAQ and PANSS also did not differ between two groups. Total time in bed, sleep latency, wake after sleep onset (WASO) and average awakening were significantly longer in patients with MetS than those of non-MetS. Sleep efficiency of patient with MetS was lower than those of non-MetS. Total sleep time and number of awakening showed no differences between two groups. Activity parameters of actigraphy were not differed between groups. Results of multiple logistic regression showed that longer sleep latency, lower sleep efficiency were high risk factors for metabolic syndrome. Dose of antipsychotics and severity of psychopathology did not associate with the risk of metabolic syndrome. Discussion(s): This may be the first study to find out the correlations of sleep quality and metabolic syndrome in schizophrenic patients by objective sleep measurements. Although some sleep parameters were correlated with metabolic syndrome in schizophrenic patients, more extensive and complicated designed studies may be needed to confirm the association of metabolic syndrome and sleep problems in schizophrenic patients.