Abstract
Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in β-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase. © 1992, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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CITATION STYLE
Sunazuka, T., Tsuzuki, K., Kumagai, H., Tomoda, H., Tanaka, H., Nagashima, H., … Omura, S. (1992). Synthesis of 1233a analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme a synthase. The Journal of Antibiotics, 45(7), 1139–1147. https://doi.org/10.7164/antibiotics.45.1139
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