PENINGKATAN AKTIVITAS SEL EPITEL PADA KASUS DENTURE STOMATITIS OLEH GEL Epigallocatechin gallate 0,5%

Abstract

Complete denture wearing patients are often associated with the presence of denture stomatitis. Poor-fitting dentures may increase mucosal trauma. It cause pressure on the mucosa and create a mechanical irritation. Epigallocatechin gallate (EGCG), is a flavonoid class of polyphenols antioxidant that have been widely researched, proven to have anti-inflammatory effects and may improve wound healing. The objective of this study was to prove the potential role of EGCG promoting reepithelialization of oral mucosa wound healing. The study was a randomized Post Test Only Control Group Design experimental study. 32 male rats (Rattus norvegicus) were divided into 2 treatment groups. The control group were given placebo gel administration (CMC-Na) for 3 days, and the treatment groups were given EGCG Gel 0.5% for 3 days. On the 6 th day, mice were euthanized for tissue sampling and histological preparations, made by HE stainning. The data were analyzed using the Independent t-Test. The mean of epithelial cleft of treatment group (549.25 ± 217.094 µm) was lower than the control group (1417.25 ± 180.572 µm), it was statistically different. EGCG Gel 0.5% increase production of Transforming Growth Factor-beta 1 (TGF-β1) to stimulate migration and adhesion of epithelial cell. Thus, it is concluded that EGCG gel 0.5% enhance reepithelialization on mucosa wound healing of Denture Stomatitis.